Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats
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چکیده
منابع مشابه
Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats
Neuropathic pain remains as the most frequent cause of suffering and disability around the world. The isomers paeoniflorin (PF) and albiflorin (AF) are major constituents extracted from the roots of Paeonia (P.) lactiflora Pall. Neuroprotective effect of PF has been demonstrated in animal models of neuropathologies. However, only a few studies are related to the biological activities of AF and ...
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Despite extensive investigations, the main mechanisms underlying neuropathic pain development are still not fully understood and there is no effective treatment for that. So intensive research is being done for finding new, efficient analgesic drugs. 56 male Wistar rats (230±30) were divided into 7 groups (n=8); control, sham, CCI and 3 Umbelliprenin groups (25, 50 and 100 microgram/rat)...
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Aberrant neuronal activity in injured peripheral nerves is believed to be an important factor in the development of neuropathic pain (NPP). Channel protein pCREB of that activity has been shown to mitigate the onset of associated molecular events in the nervous system, and sodium hydrosulfide (NaHS) could inhibit the expression of pCREB. However, whether NaHS could relieve the pain, it needs fu...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2016
ISSN: 1741-427X,1741-4288
DOI: 10.1155/2016/8082753